Exact(2)
Some genetic factors for medication overuse have also been described.
In practice, it has been argued, when frequent headache and medication overuse have coexisted for a month, both have usually been present for much longer[4].
Similar(58)
However, significantly more with than without medication overuse had co-occurrence of migraine (p = 0.001).
Chronic migraineurs with medication overuse had higher score of cephalalgiaphobia than those without medication overuse (p < 0.001).
Among them, medication overuse has become a major issue in chronic migraine patients who may eventually develop a disabling condition called medication-overuse headache [5].
Medication overuse has been recognized as a possible predictor of migraine transformation, but the mechanism has not been determined [2, 29].
In one study, 78% of adults with chronic daily headache including those not due to medication overuse had a prior history of episodic migraine.
Thus, it is reasonable to assume that the medication overuse had persisted for at least 3 months in the majority of the included participants with medication overuse at baseline.
They criticized that the primary clinical observation for the concept of MOH, i.e. improvement of headache after discontinuation of medication overuse, has never been demonstrated in a placebo-controlled trial, and has yet to be formally proved [32].
Prophylactic treatment may be indicated in patients with chronic tension-type headache if the effect of non-pharmacological treatment is insufficient and when medication overuse has been excluded [25].
Sudden withdrawals from medication or overuse have to be managed.
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