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The most common acute secondary headaches are induced by alcohol, fever, hunger and rhinosinusitis and are usually paroxysmal [5], but secondary chronic headache (≥ 15 days per month ≥ 3 months or ≥ 180 days/last year) is also common and medication overuse contributes to the problem [6, 7].
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Realising that medication overuse may be contributing to increased headache seems important for the successful treatment of MOH and thus more research on this stage is needed.
All this is highly hypothetical as correctly pointed out by the authors and may or may not stress the possibility of many different drugs that may cause medication overuse headache or may contribute to the development of chronic headache in particular patients.
OF hypofunction impairs reward and decision-making mechanisms [7, 8], occurs in substance abusers, and could contribute to medication overuse in CM patients.
In women with chronic migraine, the reduction in pain medications used contributes to prevent medication overuse headaches.
Among risk factors, migraine frequency and acute medication overuse are believed as important targets contributing to the transformation from episodic to chronic migraine.
Maybe medication overuse and/or peri-ictal testing may have contributed to the MSPA reduction reported in chronic migraine [7, 8].
Two classes of medication use, use of anti-depressants and medication overuse, were also examined because each may contribute to confounding of the link between depression and transformation to CM.
Roughly half of chronic daily headache patients, Silberstein estimates, developed the problem from medication overuse.
Without medication overuse 1.2.
medication overuse headache.
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