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Sample characteristics at T0 and T1 regarding migraine frequency, aura status and medication overuse are reported in Table 1.
After treatment, relapse rates of chronic headache (≥15 days/month) combined with medication overuse are typically high.
Among risk factors, migraine frequency and acute medication overuse are believed as important targets contributing to the transformation from episodic to chronic migraine.
However, the neurobiological mechanisms by which some migraineurs develop CM and enter the vicious cycle of medication overuse are still under debate.
In our proposal, the criteria for adequate treatment and recommendations for dealing with medication overuse are more explicit than in the EHF proposal, whereas the requirements for CSF analyses and measurement of CSF pressure are not as strict.
If patients with medication overuse are excluded, we lose the opportunity to address the benefits of treatment in a large group with disabling headache and an unmet treatment need.
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We have previously shown that medication overuse is prevalent among individuals self-medicating regular headache.
Instead of a dual diagnosis of Medication-overuse headache and Probable CM, would not a single diagnosis of CM with medication overuse be preferable in such a patient until he/she is freed from the overused drugs?
"Over-the-counter medication overuse is one of the leading causes of chronic daily headache," he said.
Patients with medication overuse were excluded.
Medication overuse was noted in eight patients.
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