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This study examined the effects of antipsychotic medication on startle latency.
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In a between-group design, 11 schizophrenic subjects on olanzapine, 16 subjects on haloperidol, and 14 subjects who were on no medication received acoustic startle testing with PPI determination.
Fear-potentiated startle (FPS) and prepulse inhibition (PPI) of acoustic startle are two widely used paradigms specifically designed to capture the impact of negative emotion (e.g. fear) and preattentive function on startle response.
CONCLUSIONS: The effects of PTSD on startle magnitude and of smoking on PPI replicate earlier studies.
Analyses described below focus on startle magnitude elicited on negative-valenced video clips, as a marker of defensive reactivity.
He does not take medication on weekends.
Use medication on minor scabies.
Give this medication on an empty stomach.
This is evidence for PB's direct action on the startle response as an enhancing agent.
Accordingly, mice were placed in a restraint tube mounted on a startle measuring platform and startle response to a loud auditory stimulus was recorded.
"It is on!" declared his startled co-host, Kate Bolduan.
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