Residues of unmetabolized APIs from parenteral and enteral drugs are excreted in feces and urine, and topically applied medications are washed from skin during bathing.
"Everything is washed away".
To assess the unique effects of the interventions, their stability over time and the need of further pharmacotherapy, medication is being washed out before the pretest to establish an unmedicated baseline and after the intervention phase in both groups.
Other exclusion criteria included adverse reactions or lack of response to previous amphetamine therapy, concomitant medications affecting the central nervous system or blood pressure (with the exception of ADHD medications that were washed out), pregnancy or lactation, a body mass index < 18.5 and ≥ 40, or a clinically significant laboratory or ECG abnormality.
Although we cannot rule out the possibility that medication has not been washed out entirely, a longer period of medication absence was not tolerated by the patients and thus, was not possible.
Prior antiparkinsonian medications were to be washed out prior to baseline, but were allowed during the study at the discretion of the investigator if extrapyramidal symptoms [EPS] emerged or worsened.
Concomitant UC medications were not allowed; for patients receiving oral 5-ASA at the screening visit, oral 5-ASA medication was required to be washed out ≥2 days and rectal ASAs had a 4-week washout prior to randomisation.
Everything is washing through.
Patients were washed out of their medications at least one month before imaging (opioids or cannabinoids were never administered).
