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All trial medication is supplied open-label.
The efficacy of pharmacotherapies is established through randomised controlled trials where the medication is supplied direct to subjects.
In our institution, all medication is supplied from pharmacy with mixing instructions checked among members of our PAH team from nursing, pharmacy and physicians.
Medication possession ratio is defined as the ratio of days for which a medication is supplied to the total days in a specified time interval.
A study overview is shown in figure 1. Trial medication is supplied directly to each patient by post from the Dundee University Research Pharmacy.
Effective pharmacotherapies are available for smoking cessation but their efficacy is established through randomised controlled trials where the medication is supplied direct to subjects.
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Medication was supplied in wallet cards that were dispensed at each visit.
More of this rescue medication was supplied upon request during the whole study period.
Both simvastatin and the placebo medication were supplied by Merck Sharp and Dohme (Sydney, Australia) in tablet form.
The subjects were informed that the medication was supplied in special containers that had to be returned to the clinic but not about the monitoring system to prevent bias.
Patients were enrolled by the participating centres and randomised 1 1 to pancreatin or placebo according to the randomisation list generated by the Pharmaceutical Supplies department of Abbott, using a block size of 8. Study medication was supplied with the randomisation codes printed on the labels.
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