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It is a truth universally acknowledged [ 1, 2] but not justified with any recent evidence, that the proportion of the population on repeat medication is high and increasing.
In such a situation, the risk of incorrect administration of a prescribed medication is high, with the potential to result in a large number of adverse events [ 26].
First, the prevalence of other known risk factors of CI-AKI, such as chronic kidney disease, diabetes, dehydration, and concurrent nephrotoxic medication is high in the elderly.
The effectiveness of osteoporosis medication is high, with relatively early results; commonly used osteoporosis agents like risedronate and alendronate significantly reduce the incidence of non-vertebral fractures (21 39 %) compared to placebo during 3 or more years of follow-up [ 26– 31].
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The cumulative proportion of psychotropic medication is higher than 100 due to combinational use of psychotropic medication.
Notably, non-fatal self-poisoning by medication is higher among females than males in Western countries [ 10].
Reported prior medication was high (42.5%).
The acceptance rate for medication was high: 83% in the CBT group and 75% in the stepped-care group.
Compliance with the medication was high, with 75% of respondents stating that the full drug course was completed (95% CI: 68.2, 80.6%).
Respondent adherence to taking medication was high (77%) but low adherence to submitting follow-up sputum (47%) was observed in this group.
Although the use of rescue medication was high across all three treatment groups, this would not be unexpected in a 1-year study.
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