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A significant time-effect showing a steady decline in depressive symptoms in all medication groups was demonstrated.
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Data from different medication groups were pooled.
Differences in these characteristics between medication groups were identified with ANOVA and a Tukey post hoc test.
Within the medication list, four medication groups were selected for analysis and correlation to renal function: metformin, NSAIDs, ACE-inhibitors/ARBs and digoxin.
Compliance rates (as defined by the patient) differed between medication groups, being highest for bisphosphonates and lowest for HRT and strontium ranelate.
After the stepwise procedure for inclusion in the Poisson regression models, the selected medication groups were both OTC and prescription medications purchased and prescribed for varying degrees of severity of ILI symptoms or complications of influenza.
Both active medication groups were statistically significantly more likely to demonstrate this level of improvement compared with placebo (p < 0.001) but not when compared to one another (p = 0.6).
As the differences between patients treated with metformin and a sulphonylurea and patients treated with metformin and a glitazone did not reach statistical significance for hypoglycaemia (p = 0.1127) or HFS-II scores (p = 0.5222), the medication groups were combined for subsequent analysis.
The index date for the PAH medication group was designated as the earliest date of a medical or pharmacy claim with evidence of PAH-indicated medication in the identification period.
The second largest medication group was anticonvulsants.
Overlap of subjects between the PAH diagnosis group and the PAH medication group was allowed.
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