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The DBI is one of the few cumulative medication exposure measures that considers the dose.
Additionally, the linkage between pharmacy submission of claims and patients' receipt and consumption of the medication is assumed and not directly measured; prior work suggests that medication exposure measures can be accurately derived from pharmacy claims (20).
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This requires further work, especially as a more accurate medication exposure measure would need to take into account whether drugs that have been prescribed are actually taken by patients, which could vary significantly depending on the type of medication.
Medication exposure in days was measured from enrollment until death, disenrollment or the end of the study period December 31 , 2008
Still, these analyses are subject to biases that might be introduced by making assumptions about ongoing medication exposure or carrying forward A1C measures that may be too far removed from treatment.
Polypharmacy as a measure of medication exposure can be difficult to quantify, especially from integrated data such as that in SIR, where dosage and intake instructions need to be inferred through text mining.
This study used pharmacy claims records to measure adherence, and thus our analysis assessed rates of medication acquisition rather than medication exposure.
The ORs were the measure of the odds of exposure in the case window versus the control window; specifically, medication exposure in the week before the MVA (case window) was compared with medication exposure during the same week of the control window, 1 year earlier.
Medication Exposure in Pregnancy Risk Evaluation Program.
Accurate assessment of medication impact requires modeling cumulative effects of exposure duration and dose; however, postmarketing studies usually represent medication exposure by baseline or current use only.
We also examined length of stay and discharge disposition by anticholinergic medication exposure.
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