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The Unified Parkinson's Disease Rating Scale UPDRSS) motor scale (III) and total medication doses were assessed before surgery on and off medication and off medication/ON DBS (off/ON) after 6 to 12 months of STN DBS.There was a 58% improvement from bilateral STN DBS in the UPDRS III (40 ± 16 preoperatively off, 17 ± 11 off/ON) 9.6 ± 1.9 months after surgery (P <.001).
Medication doses were compared using the Wilcoxon rank sum test.
After 4 weeks of active treatment, the medication doses were doubled.
Medication doses were not recorded; the most commonly prescribed doses were assumed.
Outlying data points for OAD and injectable medication doses were defined as values ≥200% of maximum daily doses.
The open-label medication doses were increased during a titration period of 4 weeks until reaching 20 mg daily.
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Medication doses are dialed down.
Medication doses are given as the maximum drug dose during the first 24 hours.
This suggests that the effect of repeated medication doses is cumulative.
Consistent with the literature, this study has found that the number of daily medication doses was significant in influencing one's preference to continue with a medication [ 26].
In patients not at goal, and in those receiving active vitamin D preparations or recombinant human erythropoietin supplementation, data are obtained monthly, and medication doses are adjusted accordingly.
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