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For patients requiring rescue medication, data obtained after rescue were excluded from efficacy analyses.
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Medication, diabetes care use: Total required insulin dose (every 3 months this will be self-reported in the web-based questionnaire); Time delay to reach stable insulin dose (i.e. HbA1c < 7.0%); (Oral) medication changes (data obtained from pharmacy and GP); Frequency of contacts with health care providers (every 3 months this will be self-reported in the web-based questionnaire).
Sociodemographic information, self-reported medical history, lifestyle, and medication data were obtained using nurse interview.
Medication data were obtained from all outpatient and inpatient pharmacies throughout Sweden.
Diabetes medication data were obtained from 4.5 years of outpatient and inpatient pharmacy records from all health care settings throughout Sweden.
This nationwide longitudinal study monitors the trends of lipid-lowering medication and factors related to medication use in individual-level data obtained from linkages between health insurance and care registers covering the whole population.
At times, family members took part in several studies at once -- a violation of the rules because studies require that participants not be taking other medications, so that the data obtained relate only to the drug under study.
The Proportion of Days Covered (PDC), a measure of adherence, will be calculated for all diabetes and hypertensive medications using the prescription fill data obtained from pharmacies.
All efficacy data obtained after the introduction of rescue medication were excluded from the analysis.
Data obtained included systolic blood pressure, serum creatinine, vasoactive medication use, urine output, and intravenous fluid.
Supplementary data obtained from participant's records on socio-demographics, clinical characteristics, medication utilization, and HRQoL was also collected.
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