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Each cocaine dose was tested twice under each medication condition, and the order of medication condition and cocaine dose were varied systematically.
Each cocaine dose was tested twice under each medication condition, and the order of medication condition and cocaine dose varied systematically.
Under each medication condition during inpatient phases, participants smoked a sample dose of cocaine base (0, 12, 25, and 50 mg) once, and were subsequently given five choice opportunities, 14 min apart, to self-administer that dose of cocaine or receive a merchandise voucher (US$5.00).
Under each medication condition, participants smoked a sample dose of cocaine base (0, 12, 25, and 50 mg) once, and were subsequently given five choice opportunities, 14 min apart, to self-administer that dose of cocaine or receive a merchandise voucher ($5.00).
The 2 (medication condition; Med) X 6 (T) repeated-measures ANOVA tested the main effect of medication condition (Med) and its interaction with time (Med X T), separately for the encoding and decision phases.
This lack of significant effects in the medication condition could relate to the suboptimal pharmacological treatment.
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The patients with other medical disorders and complicated medication conditions were excluded from this study.
See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
The associated activity in brain regions that are known to support this type of learning was indistinguishable between the placebo and medication conditions, demonstrating the power of expectations to elicit changes in the brain.
No significant activation differences were observed between medication conditions.
It is possible that important differences may exist for certain disease states or medication conditions.
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