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Symptomatic patients received corticosteroid medication as required.
This typically involved rest and medication, as required.
This typically involved usual contact with a person's regular care team, maintaining scheduled appointments, adhering to medication as required or attending groups as per their normal programme.
Patients receiving ICS at the start of the study could continue with their medication and all patients were provided with salbutamol/albuterol metered-dose inhaler (100 μg per actuation) as rescue medication, as required during the trial.
Over 75% of patients remained on therapy for one year which at least in part may be attributable to patient and investigator perceived clinical improvements in manic, depressive and anxiety symptoms and the flexibility psychiatrists had to alter medication as required.
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However, due to ethical considerations, medication was permitted as required.
Pro re nata (PRN) medication usage specifically sleeping and as required psychotropic medication will be measured using a weekly self-report diary, and patient notes whilst admitted as an inpatient.
We will include trials that allow for rescue medications (as required, short-term, infrequent use aimed at emergent symptom relief only) as long as these medications were equally applied among the randomized arms.
Rescue medication (buprenorphine sublingual tablets 0.2 mg) was allowed as required.
Glaucoma medications were continued after cyclodiode treatment and adjusted later as required.
The patient drug administration screen listed all regular medication before as required and once-only orders.
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