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Control children did not have any clinically relevant diagnoses or took any medication as reported by the parents.
Use of antihypertensive medication, as reported by women at baseline, showed a weak positive association (adjusted relative risk, 1.4, 95% CI, 0.8 2.2, Table 2).
For the US sample, depression was defined by self-reported medical diagnosis in the 12 months prior to the interview or prescription of antidrepssant/anti-anxiety medication as reported in clinical charts.
Also, adherence and persistence were estimated based on the presence of a claim for a filled prescription rather than real consumption of the medication as reported by patients or assessed by objective measures.
A telephone interview was conducted by trained personnel, using a standard structured questionnaire to gather information on adjuvant oral endocrine therapy, adherence and problems experienced in taking the medication as reported by the patient.
The study definition of hypertension included individuals who had either BP levels above the WHO cutoff points or a diagnosis of hypertension (by a physician) in conjunction with use of anti-hypertensive medication, as reported in the interview questionnaire.
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We hypothesized that after a few years in university, students would be more aware of the risks of self-medication, as reported by Sapkota et al. [ 21].
These patients suffered from AF for 6.6 years on average, and took a mean number of 6.6 long-term medications as reported by the treating physician.
Medication use as reported by the controls was verified by reviewing prescription databases.
Table 1 shows the reasons for medication changes as reported by physicians and patients.
Hospitalisation data (events) will be collected as part of 'adverse event' reporting and HF related medication data as reported by patients will be captured by the research nurse at the research clinics.
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