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In conclusion our data indicate a positive impact of desogestrel 75 μg on migraine frequency, intensity, use of pain medication and quality of life.
To study the effect of the POC desogestrel 75 μg on migraine frequency, intensity, use of acute medication and quality of life in a clinical setting over the period of 180 days.
The agreement between questionnaire and interview with respect to diagnosis was less than 50% for headache on ≥15 days/month, frequent use of headache medication and quality of headache.
Adherence, difficulty in taking medication and quality of life were assessed by patient and/or caregiver's self report.
We hypothesize further that case management leads to a greater increase in adherence (medication) and quality of life.
A second limitation is the fact that the psychosocial risk factors for non-adherence, i.e., HIV-stigma, depressive symptoms, beliefs about medication and quality of life yielded significant inter-correlations of moderate magnitude (data not shown).
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Clinical trials that use subjective measures as endpoints usually evaluate outcomes such as symptom scores, the need for rescue medication, and quality-of-life measures.
An important strength of the present study is the long run-in period and the evaluation not only of migraine frequency but also of additional parameters, like pain intensity, use of pain medications and quality of life.
The acute phase included the following measures: demographic data, psychiatric history, functional health status, clinical condition, drug already received and prescribed at baseline, concomitant medications, and quality of life.
Castle [ 5], for example, has shown a positive association between NHA turnover and the resident outcomes of catheterization, restraint use, pressure ulcers, psychoactive medications, and quality of care deficiencies.
Medication-related problems (eg, adverse drug reactions), medication adherence and quality of life were included as secondary outcomes.
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