The continued characterization of the interaction between tumor epithelial cells and stromal elements and the molecular identification of key mediators will likely provide insights into tumor biology and suggest novel therapeutic options.
Therefore, a more complete understanding of how the downstream molecular mediators of Axl function will provide critical information to help design strategies to augment EGFR-TKI efficacy.
It is important to define the mechanistic pathways induced by physiologically relevant mechanical signals in the presence of proinflammatory mediators, because this information will provide key parameters for the safe application of pharmacological therapies, in conjunction with biophysical treatments for OA.
Better understanding of the relevant mediators of inflammatory insulin resistance will provide potentially clinical relevant information.
Christopher Dalbey, an attorney who represents more than 100 families, said he was pleased that the gas company will provide a mediator — likely to be a retired judge — to resolve disputes over the size or speed of a relocation.
If proved, this hypothesis will provide another mediator of EPCs senescence, and may establish a novel pathogenesis for DM and further benefit to the management of DM.
Characterization of the roles of these important uveitic mediators in the ocular inflammatory response will provide information critical to the understanding of the pathogenesis of intraocular inflammation so that more effective therapeutic intervention(s) can be developed.
These data, when combined with demographic and efficacy data, will provide insight into the mediators and moderators of change in walking behaviour.
Furthermore, the study will provide valuable insights into motivational mediators and moderators for adherence to intensive lifestyle treatment.
A public appeal from Annan and fellow mediators, including the Sinn Féin president, Gerry Adams, for Eta to embrace peace will provide the group with an excuse for declaring its readiness to abandon arms, according to sources.
