Sentence examples for mediators which activate from inspiring English sources

Angiogenesis involves cell surface-bound and soluble angiogenic mediators, which activate vascular ECs (Table 4).

During the DNA damage response (DDR), the sensor kinases Tel1 and Mec1 in Saccharomyces cerevisiae and ATM and ATR in human, phosphorylate multiple mediators which activate effector proteins to initiate cell cycle checkpoints and DNA repair.

We chose to investigate Ang II, an important vascular mediator which activates PKCε in cardiomyocytes and up-regulates HO-1 in EC.

Surfactin generates the reactive oxygen species (ROS), which activate the mediator of survival and JNK and ERK1/2, which are the key regulators in apoptosis.

Ligand interactions with the TLR4 complex result in the recruitment of multiple adaptor molecules to the cell membrane which activate NF-κB leading to inflammatory mediator release.

The best characterized of these electrophile mediators is HNE, which activates and inhibits complex networks of cell signaling and gene expression, induces the intrinsic and extrinsic pathways of apoptosis, and modulates the inflammatory response at the cellular level.

The superoxide, accumulated in the cells pre-treated with GA, may act as a mediator of adaptive ROS signal which activates pathways linking the cellular antioxidant response to unfolded protein response (Sarbassov and Sabatini 2005) as shown by the concerted up-regulation of key enzymes of the radical scavenging systems such as MnSOD and catalase.

Hiro stubs his toe which activates Baymax.

These are potent inflammatory mediators, which target and activate the renovascular endothelium, leading to local platelet aggregation and microvascular thrombosis.

It is likely that it mediates its effect indirectly via activation of mast cells in the superficial airway to release mediators, which in turn activate local cough receptors.

The inflammatory reaction is capable of activating the synthesis of several lipid mediators which are involved in the complex regulation of the inflammatory process [ 6].