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When studies focused on the cytokine levels in joint fluid of arthritic rodents, a limited number of mediators were addressed [ 19, 21] or assays were restricted to cytokines, such as TNF-α, IL-1β, or IL-6, that have a well-known pathogenic role [ 22].
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Dropout can be addressed among parents, through school mediators, with staff trained to spot signs of potential school abandonment early, and address the issues proactively.
Absence of cellular and humoral mediators of inflammation in this artificial CSF could be addressed in future studies by using CSF from patients with proven shunt infection.
The role of ROS as mediators of senescence and determinants of lifespan has been addressed by genetic studies in several model organisms (for a review, see [ 1]).
The use of such a tool enables stakeholders and mediators to formulate explicitly the problems that need to be addressed in the decision-making process.
Studies to date have used different cut-offs to define vitamin D deficiency, which can potentially be addressed with a dose response assessment of this mediator.
AMPK-independent control of mTOR was addressed by John Blenis (Harvard Medical School, USA), who discussed the possible role of mTOR stabilizing proteins as mediators of mTOR inactivation upon energetic stress.
This issue has been addressed by the addition of a descriptive paragraph in the subsection "Integrative modeling of Mediator complex", immediately preceding our description of the modeling pipeline.
A key question that remains to be addressed in future studies is whether increased concentrations of luminal PAMPs serve merely as markers, or as mediators of IBDs.
What has been addressed utilizing powerful genetic tools, RNA profiling and metabolic phenotyping has garnered a better understanding of the Mediator complex and its role in CVD.
Environmental epidemiology research is addressing epigenetic mechanisms as mediators of environmental exposure on disease risk or just as biosensors of exposure even if not mechanistically relevant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com