Sentence examples for mediators to regulate from inspiring English sources

The above molecules could be possible mediators to regulate EIF5A2-induced gelatinolytic activity of MMP-2.

Transforming growth factor-β (TGF-β) system signals via serine/theronine kinase receptors and intracellular Smad transcriptional mediators to regulate a large number of biological processes [ 1].

ULK1, which is known to be an initiator of autophagy, can be phosphorylated by upstream mTOR and AMPK and then transduce those signals to downstream mediators to regulate autophagy.

Seven mammalian STAT proteins such as STAT1, 2, 3, 4, 5a, 5b and 6 act as multifunctional mediators to regulate various cellular processes such as cell proliferation, differentiation, angiogenesis, and apoptosis [ 36].

These strategies often use cytokine inhibitors or intracellular mediators to regulate cytokine production, with some promising results: Approaches targeting alcohol-induced IL-1β signaling in macrophages using an IL-1 receptor antagonist (e.g., anakinra) have yielded a reduction in alcohol-induced inflammatory responses in murine liver (Petrasek et al. 2012).

Overall, intracellular LTC4 formed in lipid bodies appears to function as an intracrine, and not an extracellular autocrine/paracrine, mediator to regulate the differential secretion of IL-4 induced by IL-16, eotaxin, or RANTES [ 32].

These soluble mediators act to regulate chemotaxis, migration, growth, and differentiation of the various cell types present at the injured site.

Thus, Mediator functions to regulate transcription at multiple points in the process of gene expression.

These include chromatin modification, long non-coding RNAs (ncRNAs), microRNAs (miRNAs) and transcription elongation factors that signal to the transcriptional machinery in part through interaction with the Mediator complex to regulate gene expression [11,12].

The R3 methylation status determines the interaction with the SWI/SNF complex and with the Mediator complex to regulate endogenous target genes and cell differentiation in an MAPkinase signalling-dependent manner.

The multisubunit modular complex Mediator, known to regulate chromatin looping for gene activation (Poss et al., 2013), was enriched at SEs, and its depletion resulted in downregulation of SE-associated genes (Hnisz et al., 2013; Whyte et al., 2013).