Sentence examples for mediators to induce from inspiring English sources

During disease, microglia acquire an activated phenotype, and release soluble mediators, to induce and maintain the inflammatory response.

Injection of autologous blood might provide the necessary cellular and humeral mediators to induce a healing cascade.

Additionally, MMPs are competent inflammatory mediators to induce endothelial activation and cytokine production [ 14], thus potentially contributing to endothelial activation and dysregulation [ 5, 15, 45].

Extracellular HMGB1 thus acts as an alarmin and can activate the innate system and function in a synergistic fashion with other proinflammatory mediators to induce responses.

In the present study, we used PA as one of the major mediators to induce endothelial dysfunction by activating inflammation and reducing NO biovailability.

HMGB1 can interact with receptors that include RAGE (receptor for advanced glycation endproducts) as well as Toll-like receptor-2 (TLR-2) and TLR-4 and function in a synergistic fashion with other proinflammatory mediators to induce responses.

According to these novel hypotheses, uric acid may act as a mediator to induce endothelial cell dysfunction, thus preventing insulin-induced muscle vasodilation.

It is found that [Ru bpy)2dpp]2+ can serve as an excellent mediator to induce the oxidation of guanine, and the mediated peak currents increase linearly with the rise of guanine concentration in the range from 0.01 to 0.20 mmol L−1.

In inflammatory pain IL-1β was identified as the key mediator to induce COX-2 in spinal cord [27] and in cultured dorsal root ganglia cells [39] [42].

These results suggest that p38 MAPK is being differentially regulated by an upstream mediator to induce either cell growth or cell stress in normal wounds and chronic wounds, respectively.

Description Another model with multiple insults uses an acute inflammatory insult or mediator to induce hyperalgesia.