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MMPs and their inhibitors (tissue inhibitors of matrix metalloproteinases, TIMPs) contribute to the pathogenesis of asthma by regulating the cleavage of peptidic mediators that influence the functions and the migration of inflammatory cells and by modifying the extracellular matrix homeostasis.
Eosinophils express numerous receptors and secrete a wide variety of inflammatory mediators that influence many innate and adaptive immune responses.
The partial mediating role of SOC brings to mind that there are probably other factors or mediators that influence the relation between baseline HRQoL dimensions and the same dimensions 6 months later.
It's also known that the areas of the brain that regulate sleep patterns have "a lot of crosstalk with areas of the brain that release hormones and other mediators that influence blood pressure," Dr. Redline said.
Literature on neighborhood effects on health largely employs non-experimental study designs and does not typically test specific neighborhood mediators that influence health.
Interventions to improve dairy intake based on Social Cognitive Theory (SCT) have potential to successfully change behavior by improving mediators that influence dietary choices.
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The investigation of host mediators that directly influence endothelial function might therefore be a valuable approach to improve our understanding of the pathophysiology of sepsis.
The 'dirty', hypoxia-driven, unscheduled cell death occurring in tumour necrosis makes it likely that this process may stimulate a variety of inflammatory mediators that can influence both the systemic and local inflammatory responses.
In addition, the prognostic relevance of Wnt5a methylation may be confounded by the status of downstream canonical and non-canonical Wnt mediators that may influence the signalling response to Wnt5a loss.
EDN1 suggested a candidate pathway for exploration: we then identified CHGA-induced release of other endothelial mediators that could influence renal function, including the vasoconstrictor and pro-fibrotic EDN1, but also the pro-coagulant vWF and the pro-angiogenic angiopoietin-2.
It is also not excluded that the psoriatic inflammatory process plays a direct role via the constantly increased production of mediators that may also influence mental functions or that psoriasis and depression share common risk factors at the genetic level.
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Justyna Jupowicz-Kozak
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