Sentence examples for mediators that drive from inspiring English sources

Immune mediators that drive pulmonary host defense function like GM-CSF propose appealing alternative treatment strategies, especially if they do not only protect against IV infection itself but also against common complications like secondary bacterial pneumonia and severe damage of alveolar epithelium.

The mechanisms and mediators that drive the induction and progression of chronic inflammation, emphysema and altered lung function are poorly understood.

Pro-inflammatory cytokines, particularly tumor necrosis factor (TNF -α, and IL-1 are TNF -αt to be importand mediators that drive the pareophysiology of RA [ 1- 4].

SSc has a complex pathophysiology, and it is important to remember that the many candidate mediators that drive the disease are likely to interact extracellularly and through convergent and interacting intracellular signalling pathways.

The mechanisms and mediators that drive the induction and progression of chronic inflammation, emphysema and altered lung function are not understood, and this has severely hampered the development of effective treatments for COPD.

It is therefore important to characterize the molecular events and mediators that drive this inflammatory response, and vice versa, to identify protective factors that could provide improved therapeutic options.

The in vivo experiments in this work along with gene expression profiles from clinical samples support the idea that FT6 may be one of the key mediators that drives bone metastasis.

In this respect, we have shown that the sole human cathelicidin termed LL-37 not only has anti-meningococcal activity [8], but also interacts with meningococcal lipooligosaccharide (LOS) and as a consequence, inhibits release of pro-inflammatory mediators that is normally driven via a TLR4/MD2 receptor complex [9].

In addition to gene mutations, copy number alterations of EGFR, KRAS, PIK3CA and other signaling mediators are also critical factors that drive cancer development and determine prognoses and the sensitivity to anticancer drugs.

The stimulation particularly by hepatitis B or C infection can activate host immune mechanisms to drive serum functional mediators that reflect inflammatory processes and modulate liver regeneration.

It is therefore entirely possible that principal mediators defined thus may not reach statistical significance, since they may carry out their function for a limited period of time and drive the production of other mediators that would in fact remain statistically elevated to a degree sufficient to be detected by MA.