Sentence examples for mediators that activate from inspiring English sources

One of the effects of these mediators on the host is the induction of matrix degradation and bone resorption through activation of proteases and other inflammatory mediators that activate osteoclasts.

However, inflammatory GPCR activation can also cause store depletion following acute injury, although mediators that activate the same receptor signaling mechanisms often yield differential cellular results.

The onset of angiogenesis depends on the release of proangiogenic mediators that activate endothelial cells (ECs) and initiate their proliferation and migration [ 3].

Although naturally occurring lipid mediators that activate PPARs have been identified in vitro, establishing the physiological relevance of many of these substances as regulators of PPARs in vivo is challenging, due to their low concentrations and relatively low affinities to PPARs.

The elevated Ninj1 expression enhanced the activation of macrophages by promoting the interaction with AECs, leading to increase in pro-fibrotic mediators that activate fibroblast.

While pathways that govern IFN-I have been extensively investigated, the molecular mediators that activate host cell apoptosis during viral infection are less known.

In turn, these complex and changing subpopulations of T-cells with evolving phenotypes and functions produce diverse mediators that also activate and/or recruit successive waves of other immune effectors (macrophages, neutrophils, dendritic cells, etc)., as well as epithelium and many mesenchymal cells.

Exposure to PM is also associated with a systemic inflammatory response that involves increased circulating levels of inflammatory mediators that can activate endothelium.

Inflammatory mediators that are activated earlier in involution probably signal the influx of macrophages that are seen in increased numbers at day 4 involution [ 25].

An increase in the amount of platelets may represent a component of that complex network of cells and inflammatory mediators that are activated following injury in order to repair and regenerate the damaged tissue.

In view of this, most of the scientific and medical research has been directed towards measuring the progression and inter-relationship of mediators that are activated or suppressed following major surgery.