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These multiple mediators provide a host of targets for therapeutic intervention.
In conclusion, breast fibroblasts, particularly under the influence of inflammatory mediators, provide a potentially rich source for PGE2 production in breast tumours, whereas significant contributions from the epithelial tumour component may be restricted to cancer cells exhibiting an invasive phenotype.
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Electron-conducting metals are also utilized as electron mediators, providing a direct electron pathway between the two reaction centers.
Recently, biocatalytic degradation using ligninolytic enzymes such as laccase along with redox mediators provides a promising approach for their removal from water and wastewater.
The uptake and processing of P-Dex by macrophages and fibroblasts, and downregulation of proinflammatory mediators, provides an explanation for the sustained anti-inflammatory efficacy of P-Dex in this model of inflammatory arthritis.
This mediator provides a link between the user interface and the application functionality triggered by the user.
In Vygotskian terms, the learner's social interaction with the mediator provides a model that the learner can imitate and transform, developing beyond his current capabilities, or beyond his ZPD.
Taken together, the newly defined modular organization of the core Mediator provides a structural framework for understanding the function of Mediator in PIC assembly.
Of various signalling cascades involved in inflammatory processes, the NF-κB pathway has drawn extensive attention as a key mediator providing a link between inflammation and tumorigenesis (Karin, 2006).
Experimentally manipulating the mediator provides an approach to solving these problems, yet these methods contain their own set of challenges (e.g., Bullock, Green, & Ha, 2010).
The kinase module of the mediator provides an alternative platform for pTEFb recruitment.
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