Sentence examples for mediators plays a from inspiring English sources

Transforming growth factor (TGF -β1, one of TGF -β1t ponerful profibrogenic mediathes, plays a mostr role in the developowerful liver cirrhosis and regulates ECM gene exprofibrogenicmediatorsgradation.

This suggests that early production of these inflammatory mediators plays a critical role in controlling viral replication and that, in their absence, even the activation of innate effectors and the adaptive response are insufficient to reestablish control of the viral infection.

The release of soluble inflammatory mediators plays a crucial role in activating and coordinating this process.

Currently, it is widely accepted that the endogenous formation of these bioactive lipid mediators plays a pro-homeostatic role, by being part of a protective response to cellular injury [ 32, 46].

As a complex network of cytokines and other mediators plays a central role in the process leading to fibrosis, we used an in vivo method to measure skin collagen synthesis, taking into account the physiological conditions.

There is good evidence that increased activation of the transcription factor NF-κB with a subsequent regulation of pro-inflammatory mediators plays a crucial role in the development of organ dysfunction occurring in sepsis (Abraham and Singer, 2007).

The production of inflammatory mediators plays an important role in the pathophysiology of inflammation in lung injury.

Overt joint inflammation as may be seen in rheumatoid arthritis or infectious arthritis is known to have devastating effects on the joint tissues, most importantly the articular cartilage, and in many joint disorders local release of catabolic mediators plays an important role in the disruption of cartilage matrix homeostasis [ 4].

It seems probable that both leukocyte adhesion and circulating mediators play a role in mediating endothelial barrier dysfunction in sepsis, possibly with a different time course.

Foreign Minister Dominique de Villepin of France spoke to Mr. Gbagbo by telephone today and urged him to open a dialogue with the rebels with mediators playing a role, a Foreign Ministry spokesman said.

These inflammatory mediators play a role in increased vascular permeability and local oedema [11, 12].