Sentence examples for mediators of tissue from inspiring English sources

Key mediators of tissue remodelling following brain injury or disease-mediated insult include the MMPs (matrix metalloproteinases).

Background: Oxygen free radicals have been implicated as mediators of tissue damage in patients of rheumatoid arthritis (RA).

These deposits of foreign protein and complexes react with other protein components of blood (see the article complement) and attract to the site white blood cells and platelets, which also are circulating in the blood; these in turn release protease enzymes and other chemical mediators of tissue injury.

Extensive in vitro experimentation implicates M2 macrophages as the primary mediators of tissue fibrosis, however, the data from in vivo studies present a more complex picture.

Peripheral sensitization is usually the result of exposure of nociceptors (i.e., receptors that respond to a noxious stimulus) to inflammatory products and mediators of tissue injury.

Among the mediators of tissue injury, IL-1 and TNF-α are actively involved in the progression of cartilage damage and can stimulate MMP secretion from chondrocytes and synovial tissues [13, 14, 15].

Oxidative stress is a major mediator of tissue and cell injuries.

NO may also interact with the superoxide radical to yield peroxynitrite, a highly reactive mediator of tissue injury.

Our work has focused on examining the mechanisms of signal transduction by Transforming Growth Factor-beta1 (TGF-β1), a pleiotropic cytokine and key mediator of tissue injury response and kidney fibrosis.

In addition, peripheral Gr-1-positive cells of IVIG-treated animals showed reduced expression of the activating Fcγ receptor IV, which we recently described as a major mediator of tissue injury in experimental EBA.

Since oxidative stress is a key mediator of tissue damage after ischemia-reperfusion, the role of SIRT6 in oxidative stress-induced neuronal injury remains to be investigated.