Sentence examples for mediators of systemic from inspiring English sources

TNF-α and IL-6 act through classical receptor-mediated processes, resulting in upregulation of potential mediators of systemic inflammation that can lead to insulin resistance.

In this complex scenario, our study was designed to verify the existence and strength of the association between selected mediators of systemic inflammation and classic risk factors of cardiovascular diseases (CVD).

With body mass index, adipokines, and mediators of systemic inflammation forced into a multivariable linear regression model with waist-to-hip ratio, we observed no significant attenuation of the effect of abdominal obesity on telomere shortening (Table 4).

For example, TNF-α is one of the key mediators of systemic endotoxemia.

The infection either spreads into the bloodstream and results in positive blood cultures or grows locally and induces factors that stimulate the release of endogenous mediators of systemic inflammation [ 14].

Zebrafish neutrophils are important mediators of systemic immunity in embryos and we hypothesized that depletion of Nod1 or Nod2 might affect the recruitment of neutrophils to infection (Prajsnar et al., 2008).

Results of recent studies indicate that a single intravenous dose of GLN supplementation ameliorated lung and kidney injury and increased survival in a cecal ligation and puncture (CLP -induced sepsis model by inhibition of the high-mobility group box protein-1 (HMGB-1)-mediated pathway, whiCLP -inducedht to be a late-sepsismodeltor of systemic damage [ 14, 15].

These findings suggest that HMGB1 is an important mediator of systemic autophagic syndrome.

Stat1 is a key mediator of systemic IFN responses (Stark and Darnell, 2012).

In animal models of infection or local tissue injury, HMGB1 functions as a critical mediator of systemic or local inflammatory injury [ 11].

HMGB-1, recently known as the "late" proinflammatory mediator of systemic inflammation, has been shown to activate MAP kinase and NFκB signaling through RAGE (Sims et al. 2010).