Sentence examples for mediators of severe from inspiring English sources

Hypothalamic peptides and receptors of the corticotropin releasing factor family have been identified as putative mediators of severe burn-induced hypermetabolism [ 69, 70].

HSV-1 isolated from lung secretions may thus be a marker rather than a mediator of severe illness.

Enterohemorrhagic Escherichia coli (EHEC), the mediator of severe food- and water-borne disease, can breach this barrier and adhere to intestinal cells.

Consequently, it may be premature to rule out VEGF as a mediator of severe malaria, given its diverse functions.

Notably, haem has recently been implicated as a key mediator of severe systemic inflammation in sepsis.

In animal models, HMGB-1 is a mediator of severe sepsis, and an anti-HMGB-1 antibody decreased mortality in the CLP model of sepsis [ 6, 12, 16].

Production of peroxynitrite has been described in organs remote to the site of severe burn injury, making it an important mediator of severe burn-induced multiple organ failure [ 52, 53].

Recently, increasing attention has focused on.NO as a possible mediator of the severe hypotension and impaired vasoreactivity characteristic of circulatory failure.

Zhang et al. have demonstrated that HMGB1 was upregulated in patients with severe acute pancreatitis, which may seem to act as a late cytokine mediator in the pathogenesis of severe acute pancreatitis [ 7].

The findings in our study have indicated that serum HMGB1 levels were significantly increased in patients with pancreatitis and were correlated with disease severity, suggesting that serum HMGB1 concentrations can be regarded as an important cytokine mediator in the pathogenesis of severe acute pancreatitis.

To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat.