These results imply a critical role for both GalR1 as well as the galanin cascade itself as mediators of post-seizure-induced damage.
Our findings that GalR1 gene-deleted mice are strikingly more susceptible to seizure-induced cell death are in agreement with previous studies [35], [42], [56], and implies a critical role for both GalR1 as well as the galanin cascade itself as mediators of post-seizure-induced damage.
The 80 miRNAs can be considered as mediators of post-transcriptional cross-talks between Notch and TGF-β pathways.
MicroRNA (miRNA) molecules are potent mediators of post-transcriptional gene silencing that are emerging to be critical in the regulation of innate and adaptive immunity.
They have shown that excitotoxicity and neuroinflammation are critical mediators of post-HCA neurological injury, and that the drug valproic acid (VPA) partially mitigates excitotoxic injury.
This integrated approach led to the identification of COUP-TFII and the glucocorticoid receptor as potential mediators of post-MI LV remodeling.
Thus, using an unbiased approach to study post-MI LV remodeling in a physiologically relevant large animal model, we identified COUP-TFII and GR as potential key mediators of post-MI remodeling.
Specifically the unfolded protein response (UPR) was examined as a mediator of post-storage stress response given its recent link to preservation failure in other cell systems.
Specifically the unfolded protein response (UPR) was examined as a mediator of post-storage response given its recent link to preservation failure in other cell systems.
The free radical NO, when produced at high levels by the inducible NO synthase and typically detected in biofluids as its reaction products NO2−/NO3−, is a critical mediator of post-T/HS inflammation [23].
Furthermore, mitochondrial calcium overload during reperfusion is an important mediator of post-resuscitation myocardial dysfunction [ 50].
