Sentence examples for mediators of pathogenesis from inspiring English sources

Recent evidence suggests that mitochondrial dysfunction and nitrosative/oxidative stress are key common mediators of pathogenesis.

The newly identified host mediators of pathogenesis could be the future target for diagnostic and therapeutics purpose.

Oligomeric forms of alpha-synuclein are emerging as key mediators of pathogenesis in Parkinson's disease.

pDCs have also been implicated as key mediators of pathogenesis in SLE [ 9, 10].

Leptospiral immunoglobulin-like (Lig) proteins are of great interest due to their ability to act as mediators of pathogenesis, serodiagnostic antigens, and immunogens.

Such mutations may be hypothesized to exist in the dhps gene itself, in loci which mediate DHPS expression and thereby parasite fitness in the presence of drug, or in heretofore undescribed mediators of pathogenesis.

Our data suggest that type 1 IFN is an essential mediator of pathogenesis in T1D and that this role results from the negative effect of IFN signaling on the survival of splenic CD8 + T cells.

These current findings further support the hypothesis that saeR/S is a critical mediator of pathogenesis during staphylococcal disease.

These proteins may serve as potential mediators of the pathogenesis of PsA, and should be further investigated in functional experiments.

For instance, CD40 ligation on synovial cells induces TNFα and IL-1β production, critical inflammatory mediators of RA pathogenesis [ 12].

Levels of several mediators of arthritis pathogenesis, synovial hyperplasia and articular damage were also reduced in DA.F344(congenicsngenics, underscoring the importance of the gene accounting for this locus.