Sentence examples for mediators of integrin from inspiring English sources

These molecules are biosensors and mediators of integrin receptor modulation, cell/cell adhesion, and thrombus formation.

The focal adhesion kinase (FAK) family kinases, including FAK and proline-rich kinase 2 (Pyk)2, are the predominant mediators of integrin αvβ3 signaling events that play an important role in cell adhesion, osteoclast pathology, and angiogenesis, all processes important in rheumatoid arthritis (RA).

Jung [44] showed that radiation-enhanced cell adhesion and invasion are associated with increased expression and/or activation of various focal adhesion molecules, such as FAK and Paxillin, which are critical mediators of integrin-activating signaling to promote cell migration.

While SKAP-55 has been established as a mediator of integrin adhesion in T-cells, an outstanding question has been whether the adaptor can regulate other aspects of T-cell signaling and function.

The key mediator of integrin signal is focal adhesion kinase (FAK) which functions in cell motility and proliferation [ 28, 29].

Focal adhesion kinase (FAK) has been described as a critical mediator of integrin signaling, allowing FAK to influence a variety of processes, including the broadening of the cell attachment, migration, survival and cycle progression.

We identified α1β1 integrin as a newly identified receptor for type XVIII collagen and observed similar defects in the cell survival response in mice deficient in α1β1 integrin and hepatocyte integrin linked kinase (IlkHepKO), a potential downstream mediator of integrin activation.

As integrins do not have intrinsic enzyme activity, FAK is a critical mediator of integrin-induced signaling events.

These results indicate that PI3K/Akt pathway may be a specific mediator of integrin-dependent cell attachment in OCUM-2MD3 cells.

The involvement of p130Cas/BCAR1 in numerous pathways driving mammary cell transformation is due, at least in part, to its function as a mediator of integrin-dependent signalling.

Both ILK and Pinch1 are known downstream mediators of β1 integrin, and numerous studies have implicated Rac1 in β1 integrin signaling (Berrier et al., 2002; Yu et al., 2005; Jeanes et al., 2012).