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The pro-opiomelanocortin (POMC -derived POMC -derivedelanocyte-stimulating hormone, and adrenocorticotropeptidesone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor.
We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes.
Furthermore, ultraviolet B irradiation had no effect on release of granulae stored mediators of human mast cells [19].
The fact that some of the genes found to be under balancing selection are exactly those encoding the major mediators of human autoinflammatory and autoimmune pathologies is relevant.
Kang et al. [ 180] and Chung et al. [ 181] investigated the action of salmosin on integrin receptors, which are mediators of human tumor cell proliferation.
Such information will be highly relevant to researchers and clinicians who wish to acquire an up-to-date understanding of this emerging field and elucidate or identify possible targets for investigation involving miRNAs as important underlying mediators of human cancers.
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We were able to demonstrate for the first time the role of MPO as mediator of human platelet activation.
Interestingly, our previous work has implied B4GALT1, a kind of glycogene, acts as a MDR mediator of human leukemia K562 cell line.
Our data suggests that TGF-β may act as a physiological mediator of human germinal centre homeostasis via regulation of BIK and BCL-XL.
Self-interest (a predominant factor in the instrumental category) per se is widely viewed as a key mediator of human motivation and is a powerful determinant of an individual's actions [ 52].
IL-10 is a well-known mediator of human B cell differentiation that has a powerful effect on the stimulation of immunoglobulin secretion by B cells in SLE [ 44].
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