Sentence examples for mediators of host from inspiring English sources

Toll-like receptors (TLRs) are essential mediators of host immunity.

We identified a number of uncharacterized genes (ZNF300, NUP1333, KLK1 and others) and confirmed previous studies demonstrating specific genes/genesets that are important mediators of host immune responses and that displayed associations with antibody response to influenza A/H1N1 vaccine.

This screen identified TFP, ExoU, and T3SS components as critical mediators of host cell death [20], [21].

Thus, CD40−/− mice are susceptible to ocular and cerebral toxoplasmosis despite upregulation of key mediators of host protection: IFN-γ, TNF-α and NOS2.

Because type I interferons (IFNs) are crucial mediators of host defense against viruses, we investigated the effect of EBV infection on the IFNα pathway in primary human monocytes.

Collectively, our data highlights IFNγ, IL-22 and IL-17 family as critical mediators of host immunity both in the acute and in the effector phase of C. jejuni infection.

Access to the genome sequence, and the associated annotation of genes and regulatory features, has provided major insight into the mechanisms of virulence and pathogenicity, mediators of host-specificity, pathogen biochemistry and physiology and adaptation to ecological niches (11 17).

Because the entire orientation of the science regarded immunity as a mediator of host defense, so-called autoimmune reactions were originally viewed as pathological.

In the present study we investigated the role of SP-A as a mediator of host defense against the pulmonary pathogen, C. neoformans.

First, acapsular strains of C. neoformans are uniformly avirulent, not clinically relevant and thus would not be suitable for investigating the role of SP-A as a mediator of host defense.

Nitric oxide (NO) is an important mediator of host defence and of vascular tone.