Sentence examples for mediators of extracellular from inspiring English sources

Alvarez, M. L., Khosroheidari, M., Eddy, E. & Kiefer, J. Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathy.

Critical enzymatic components of the OPN signal transduction pathways, PI3K, JNK1/2, Src and Akt, and mediators of extracellular matrix degradation, matrix metalloproteinase 2 (MMP2) and uroplasminogen activator (uPA), are significantly decreased following exposure to OPN-R3.

MMPs are important mediators of extracellular matrix degradation and are implicated not only in inflammatory central nervous system (CNS) diseases such as multiple sclerosis, HIV dementia and Alzheimer's disease but also in TB [5] [7].

Several MMPs and integrin genes, as well as urokinase plasminogen activator (uPA), which are all known mediators of extracellular matrix degradation and cell migration, are known targets for Ets-1 [28] [31].

The identification of syndecan-encoding sequences in multiple species of Cnidaria provides a strong indication that syndecans, like integrins, have participated as mediators of extracellular interactions throughout animal evolution.

Taken together, these expression profiles suggest that MMP-2, SPARC and SPARC-like1 are probably critical mediators of extracellular matrix remodeling and are all important in facilitating breast cancer invasion and progression.

Second, as cell surface proteins are the major mediator of extracellular stimuli that affect cells, the versatile expression of cell surface proteins may endow stem cells the ability to differentiate in response to diverse stimuli during developmental or regeneration processes.

Transforming growth factor-beta1 (TGF-β1), a key mediator of extracellular matrix accumulation, was analysed in plasma.

The PI3/AKT-signalling system is a general mediator of extracellular stimuli, including growth factors, cytokines, and adhesion, to extracellular matrices (Downward, 1998).

The cell surface receptor β1 integrin, which is present on luminal epithelial cells, is an essential mediator of extracellular matrix signalling via its ligands collagen and laminin [ 76].

It is reported that the mediator of extracellular matrix production, TGF-β, can stimulate collagen production and contribute fibrosis in DCM [ 31].