Sentence examples for mediators of altered from inspiring English sources

These findings are consistent with our observation that long-chain acylcarnitines are associated with 1-year cardiovascular mortality in ESRD [ 27], and motivate further interest in long-chain acylcarnitines as markers, or even mediators, of altered lipid metabolism and cardiovascular function in uremia.

Proteomic data are of particular value in Systems Toxicology because the proteome is an important mediator of altered biological responses as a consequence of exposure to active substances.

All these data render extracellular H2O2 and the PI3K/Akt pathway unlikely mediators of the altered eNOS phosphorylation in response to ascorbate.

The studies in the present paper support a model in which Clara cells are important mediators of the altered airway epithelial cell immune function in both human and experimental BPD.

Therefore our data suggest that the increased IL-10 secretion observed in CD83Tg B cells is one feature but not the mediator of their altered phenotype.

Therefore, we aimed to determine the role of altered pulmonary gene expression in disease inception and identify proremodeling mediators.

The activity of this mediator in the canonical wnt pathway suggests its differential regulation may be a key effector of altered osteoblast differentiation in the setting of osteoporosis.

The purposes of this study are to determine: 1) the effect of PGN and LPS on the inflammatory responses in human CAECs, 2) whether TLR2/4 levels, signaling and TLR2/4-mediated expression of pro-inflammatory mediators are altered in CAECs from T1D patients, and 3) the effect of insulin on the inflammatory responses in diabetic CAECs.

Despite these dynamic changes in inflammation biomarkers as a function of time, we sought to determine if a significant proportion of these 21 mediators were altered as a function of time.

Figure 2 shows that nearly 30% (ST) and up to 40% (ST + HS) of all queried mediators were altered over the time course studied.

Uroepithelial dysfunction in FIC further led to a peripheral upregulation of neuropeptides and inflammatory mediators that altered bladder afferent soma size and increased input to the central nervous system (CNS) [ 53].