Sentence examples for mediators of allergic from inspiring English sources

Activated mast cells, which can also produce high levels of Th2 cytokines in response to TSLP, have been identified as possible cellular mediators of allergic disorders [54].

As regulators of T cell activation, dendritic cells (DCs) are important mediators of allergic asthma, yet the precise signals which render endogenous DCs "pro-asthmatic", and the extent to which these signals are regulated by the pulmonary environment and host genetics, remains unclear.

Also, NO may stabilize mast cells [ 43] and inhibit the release of mediators of allergic phenomena.

The results are consistent with the overriding hypothesis that aeroallergens may precipitate suicide via mediators of allergic inflammation.

Mediators of allergic disease were measured 7 and 13 days after the last allergen challenge and compared to peak inflammation, 4 h post-HDM (Fig. 4A).

A few studies have suggested a possible connection between seasonality of suicide rates and aeroallergens, via mediators of allergic inflammation affecting individuals susceptible to allergy, depression and suicide.

Leukotriene C4 synthase (LTC4S) is a member of the MAPEG family of integral membrane proteins and catalyzes the conjugation of leukotriene A4 with glutathione to form leukotriene C4, a powerful mediator of allergic inflammation and anaphylaxis.

Interestingly, in spite of the well-documented role of IL-13 as a central mediator of allergic asthma [44], production of Th2 cytokines (IL-4, IL-5, IL-13) was similar in HDM re-stimulated lung cell cultures from A/J and C3H mice, while production of IFNγ was induced only in lung cell cultures from C3H mice (Figure 1b).

There is evidence for an interaction between CysLTs and histamine, another pivotal mediator of allergic reactions.

IL-13 has been demonstrated to be the central mediator of allergic asthma [ 3, 4].

Tryptase, a major secretory product of human mast cells has been implicated as a key mediator of allergic inflammation.