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Both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition.
We suggest, that this short period of disproportion between pro- and anti-inflammatory mediators may increase the 'second hit' risk, if it is longer lasting.
Inflammatory mediators may increase the excitability of lung sensory nerves that synapse, directly or indirectly, onto these cardiac vagal neurons (Undem et al. 1993).
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As the used cytokines belong to the group of pro-inflammatory mediators, the results obtained may increase our knowledge of the complex signaling network contributing to the development of inflammatory liver diseases.
In particular, high LPS concentration potentiates the secretion of pro-inflammatory mediators (P) which in turn may increase the probability of Th0 cells to differentiate into Th1 cells rather than into Th2 cells.
BRSV has a predilection for the lower respiratory tract and may damage the respiratory tract epithelium directly followed by changes induced by, i.e. inflammatory mediators [ 9] and/or it may increase the ability of bacteria to invade the lung and cause a secondary bacterial infection [ 2].
They may have adverse effects towards the vascular endothelium when produced in excess, since they may increase immobilization of inflammatory mediators at the surface of endothelial cells [101], permeability of capillaries [102], or induce direct damage to endothelial tissues [103].
The decrease in C1-INH activity may increase plasma concentration of bradykinin, the key mediator of HAE-C1-INH symptoms.
The adjustment of energy intake, however, might not be appropriate because energy intake may increase with eating rate and thus might act as a mediator rather than confounder.
The use of a more open membrane (plasmafilter) coupled with adsorption may increase the adsorptive capacity of the system and achieve higher nonspecific clearance of inflammatory mediators [ 43].
Malaria and cholera may increase.
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