Sentence examples for mediators may function from inspiring English sources

In a mouse model of Lymphocytic choriomeningitis virus (LCMV) infection wherein caspase-3 was also observed to be elevated during proliferative phases, it was suggested that pro-apoptotic mediators may function to degrade anti-apoptotic mediators and prepare cells for delayed apoptosis [38].

Other pathways and cytokines may activate and/or inhibit the system at the same point, and different mediators may function as co-determinants of the inflammatory system in parallel.

Known as potent inflammatory lipid mediators, prostanoids may function in both the promotion and resolution of the inflammatory response [ 3].

In addition, PI3K/Akt/mTOR (downstream mediator of EGFR signaling) may function as a compensatory EGFR signaling pathway; mutations in the main catalytic subunit of PI3K (PIK3CA) have been associated with primary and acquired EGFR-TKI resistance, coexisting with EGFR mutations in some cases 52, 53.

Recent studies also reveal that miRNAs may function as mediators of cell-to-cell communication.

During hypoxia elevated levels of ROIs prompted speculation that ROIs may function as common mediators of NF κB activation also.

The pleiotropic nature of gene regulation by miRNAs implies that some miRNAs may function as crucial mediators of drug resistance.

Accordingly, the transcription involved in the circadian rhythm induced by RL may function as important mediators of RL-induced resistance to DC3000.

Concomitant upregulation of bidirectional nc-rRNAs and cell death after LNA1-S and LNA4-S treatments raised the possibility that nc-rRNAs may function as death mediators.

Concurrent stabilization of nc-rRNAs and induction of cell death by the 86S and 84AS treatments raised a possibility that sense and antisense nc-rRNAs may function as death mediators.

Although moderation and mediation are distinct processes, a variable may function both as a moderator and a mediator in a single functional relation [ 60].