Exact(2)
In light of the growing evidence for a role of inflammatory mediators to affect the immune response in facilitating endometrial breakdown during menstruation [3, 4, 6, 13, 43, 51], the ability of BNO 1095 to potently inhibit release of these inflammatory mediators may explain the beneficial effect of this herbal extract in the treatment of primary dysmenorrhea.
Plasma filtration and adsorption of proinflammatory mediators may explain this improvement.
Similar(58)
Although there is knowledge about the moderators of the depression-obesity association, our understanding of the potential behavioral and cognitive mediators that may explain the relationship between depression and obesity, is scarcely researched.
Variables from the HAPA will be measured to assess the psychological mediators that may explain the effects of the intervention on the behavioural and biomedical outcomes.
This is because these factors may act as mediators and may explain the difference between home and hospital birth, and therefore holding them constant would have led to controlling for the effect of planned place of birth on PPH.
This study expanded existing knowledge by attempting to catch a glimpse of the potential mediators that may explain the association between FSS and depressive and anxiety symptoms among PLWHA employed full-time.
A potential mediator that may explain both findings could be a transient CRNK-16-induced secretion of IL-12, as IL-12 was reported to reduce corticosterone serum levels [81] and increase NK cytotoxicity [2].
Therefore, it is important to test stress as a mediator that may explain the association between sexual orientation and risk behavior.
Highly charged anionic polysaccharides similar to heparin and OSCS have also been shown to be potent mediators of the immune response system, which may explain the severe anaphylactic response observed upon administration of the contaminated heparin [ 2, 6].
That reduction in phosphorylated AKT and ERK 1/2, which are main intracellular mediators of IGF-I downstream IGF-I pathway, may explain the decrease in cell proliferation and increase in apoptosis [ 8, 32].
Similarly, it may explain how the removal of some inflammatory mediators by coupled plasma filtration-adsorption was protective in an endotoxin-shock model while levels of circulating bio-active TNF were unaffected [ 13].
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