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During sepsis, an uncontrolled cascade of inflammatory mediators is triggered, leading to tissue damage that can cause death.
The production of inflammatory mediators is triggered by the activation of Toll like receptors (TLRs) and lymphocyte antigen receptors which; through intracellular signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ) and signal transducers and activators of transcription (STATs) leads to mediator release.
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An important feature of burn trauma is a massive loss of plasma from the intravascular to the extravascular space due to systemic microvascular leakage, which is triggered by inflammatory mediators [ 1].
Bronchial inflammation, especially in allergic asthma, is triggered by a cascade of proinflammatory mediators including NO [ 51].
The activation of PMNs is triggered by the recognition of bacterial peptides and innate inflammatory mediators.
A cascade of proinflammatory events is triggered allowing for the ultimate detection of the resulting mediator molecules.
Angiogenesis is triggered by angiogenic growth factors and vascular endothelial growth factor (VEGF) is a major angiogenic mediator under physiological and pathophysiological conditions.
RBL-2H3 cells were passively sensitized with murine sera, and after removal of unbound antibodies mediator release was triggered by the addition of Bet v 1.
In brief, RBL-2H3 was passively sensitized with diluted murine serum IgE, and mediator release was triggered by the addition of antigen at 0.3 μg/mL and is expressed as percentage of total enzyme content of Triton X100-treated cells [ 12].
The board recently allocated $3.5 million for an effort that will include a hot line, community outreach, publicity, court staff and the mediators when certain criteria are triggered.
When endothelial cells are stimulated with pathogenic mediator LPS, inflammatory signals are triggered, which increase permeability and leukocyte recruitment [ 26].
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CEO of Professional Science Editing for Scientists @ prosciediting.com