Sentence examples for mediators implicated in from inspiring English sources

We demonstrate that anti-IL-1RA autoantibodies from IgG4-RD patients directly inhibit IL-1RA binding to promote the expression and production of pro-inflammatory and -fibrotic mediators implicated in the pathogenesis of this disease.

Moreover, treatment of IL-1α-stimulated A549 cells with IL-1RA and a commercial anti-IL-1RA pAb restored the mRNA and protein levels of immune mediators implicated in pathogenic inflammation and fibrosis.

However, in the present study mediators implicated in ALI such as vWF [11] were not elevated.

IPF exhibits a poor prognosis and unresponsiveness to currently available therapies, reflecting our limited understanding of the basic mechanisms and mediators implicated in the pathogenesis of this progressive and fatal disease [4], [5].

LPS is one of the most potent microbial mediators implicated in the septic response.

Leukotrienes are inflammatory and vasoactive mediators implicated in endothelium-dependent relaxations and atherosclerosis.

Such cells express PW1, a cell stress mediator implicated in TNF-NF κB signalling and p53-mediated cell stress pathways, along with Sca-1 and CD34.

Considering that NO is a key mediator implicated in a broad range of age-related skin damages, these findings suggest that resveratrol could delay and even prevent the normal course of skin aging by blocking apoptotic events and mitochondrial dysfunctions.

Follistatin-like protein 1 (FSTL1) is a proinflammation mediator implicated in arthritis in rodent animal models.

Leukotriene D4 (LTD4) is a proinflammatory mediator implicated in the pathology of chronic inflammation and cancer.

IFN-α is a further important inflammatory mediator implicated in the pathogenesis of inflammatory myopathies.