Sentence examples for mediators generated by from inspiring English sources

Therefore, limiting the expression of COX-2 would on the one hand prevent the accumulation of possible inflammatory mediators generated by COX-2-mediated 2-AG metabolism and on the other hand more 2-AG would be available for possible neuroprotective effects mediated via cannabinoid receptors.

Many signals can activate ECs and platelets in sepsis, including pathogens and mediators generated by inflammation and coagulation.

Mediators generated by cell damage such as complement activation products and histones can activate platelets [123, 124].

The observed antimicrobial activity could be a direct consequence of CD23 engagement or, alternatively, could be induced by mediators generated by this pathway.

4 The endothelium is believed to be a primary target of mediators generated by the placenta.

This process involves mediators generated by both endogenous kidney cells and by infiltrating white blood cells which are instrumental in both the initial injury and the long term recovery [ 1- 4].

The predominant endogenous chemotactic mediator generated by I/R in males was ELR+ chemokine Cxcl5 (human CXCL6 [ 15]), which had a unique temporal profile compared to other chemokines that accounts for sustained neutrophil stimulation, mobilization, and recruitment during reperfusion.

To establish whether PGE2 was indeed the main tumor-promoting mediator generated by COX-2 in our model, we used CAY10560, another inhibitor specific to mPGES, which is known to be downstream of COX-2 in generating PGE2 in zebrafish [ 18].

Thus, the release of cfDNA from host cells occurred independent of the infecting organism and hence is likely mediated by the inflammatory mediators generated during the exacerbated host response to infection.

Since our finding that lipid oxidation enzyme production was altered, most specifically ALOX15 (figure 6H), and lipid mediators generated at local tissue sites are influenced by and in turn influence accumulation of select leucocyte populations in inflammation, 36 we reasoned that eosinophils might influence the lipid mediator profile of DSS-colitis.

Dozens of different mediators have been identified including mediators released from mast cells and basophils, as well as mediators generated in the cascade of events that is activated by those cells (Wasserman, 2008; Gandhi et al., 2009).