Sentence examples for mediators derived from from inspiring English sources

This may have occurred because of mediators derived from tumor cells and/or of derivative elements in the tumor stroma [ 29- 34].

Early hypotheses embraced the concept that pulmonary fibrosis represents the end stage of an inflammatory cascade initiated following alveolar injury, and that fibrogenesis following such alveolitis was mediated by a number of inflammatory and fibrogenic mediators derived from recruited inflammatory cells.

In general, AA-derived eicosanoids, which generally exhibit proinflammatory actions, are more potent than mediators derived from EPA.

Among these identified factors contributing to uncontrolled inflammation in obesity, special attention is given to bioactive lipid mediators derived from the cyclooxygenase and 5-lipoxygenase pathways, which convert the membrane-derived AA into potent proinflammatory eicosanoids (such as prostaglandin and leukotriene).

To further investigate the potential mediators derived from PMap, we employed blocking antibodies against CCL5 and CXCL7, two platelet-derived chemokines that have been shown to mediate mononuclear cell (MC) recruitment.

Mechanical overload and activity of systemic inflammatory mediators derived from adipose tissue (adipokines, free fatty acids (FFA), reactive oxygen species (ROS)) provide clues to the increased incidence and prevalence of OA in obesity.

It is therefore important to recognize that severe burn trauma exposes the BBB to harmful proinflammatory mediators deriving from two different compartments: the brain and the systemic circulation.

Thus, during sepsis, the BBB is exposed to harmful proinflammatory mediators deriving from two different compartments, the brain as well as the systemic circulation.

Metabolism of leukotriene B4, a potent eicosanoid inflammatory mediator derived from arachidonic acid, proceeds via P450-mediated hydroxylation of the ω-terminal end of the fatty acid, followed by conversion to a dicarboxylic acid and subsequent degradation in peroxisomes.

LXA4 is a resolution-of-inflammation mediator derived from arachidonic acid, and maresin 1 is a DHA-derived mediator made by macrophages that also displays protective bioactivity.

Arita, M. et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.