Sentence examples for mediator of type from inspiring English sources

Recently a molecule called MITA/STING has been identified as an important mediator of type I interferon production by cytosolic nucleic acids [19], [20].

In addition, a recent report identified TLR2 as a mediator of type 1 IFN secretion in response to viral ligands [18].

For example, IRF3 is a major mediator of type I IFN production, important in mucosal anti-viral response; in IKKγ−/− cells, the replication of RNA viruses is significantly increased due to the inability to produce type I IFNs [15].

The overlapping transcriptional signatures of cells stimulated with IFNs is both cell subset- and IFN-specific; for example, STAT2, an important mediator of type I interferon signaling, was induced by IFNγ treatment only in the purified monocyte cell population, as were an additional 22 genes induced by type I IFNs, compared to IFNγ stimulation in PBMCs (Table S4).

It has been reported to be a mediator of type I IFNs, NF-kB, and MHC class I gene.

IRF9 is a mediator of type I IFN signaling and acts together with STAT1 and 2 to activate transcription of IFN-responsive genes.

Conclusion: The antibody response to HPV is a mediator of type-specific protective immunity, which forms the basis for prophylactic vaccine candidates.

The quantum yield of singlet oxygen photogeneration in D2O was found to be very low, which confirmed results reported by other researchers that in aqueous solutions, even functionalized fullerenes C60 with one positively charged group were very inefficient mediators of type II photochemistry and produced only a negligible amount of singlet oxygen.

STAT1, as the first discovered member of the STAT family, serves as the principal mediator of both type I and type II interferon activation [ 2].

In conclusion, our data position miR-143 as a critical mediator of collagen type III expression in scirrhous type GC.

The type II IFN, INF-γ, is the main mediator of the type I immune response and is essential in the control of mycobacterial infection in both animal models and humans [ 7].