Sentence examples for mediator of tissue from inspiring English sources
Oxidative stress is a major mediator of tissue and cell injuries.
NO may also interact with the superoxide radical to yield peroxynitrite, a highly reactive mediator of tissue injury.
Our work has focused on examining the mechanisms of signal transduction by Transforming Growth Factor-beta1 (TGF-β1), a pleiotropic cytokine and key mediator of tissue injury response and kidney fibrosis.
In addition, peripheral Gr-1-positive cells of IVIG-treated animals showed reduced expression of the activating Fcγ receptor IV, which we recently described as a major mediator of tissue injury in experimental EBA.
Since oxidative stress is a key mediator of tissue damage after ischemia-reperfusion, the role of SIRT6 in oxidative stress-induced neuronal injury remains to be investigated.
Both IL-6 and IL-10 have been shown to be associated with stimulation of the Th2 pathway and activation of anti-inflammatory cascades, and they may also inhibit TNF-α, which is a potent mediator of tissue damage [12, 23 25].
Membrane-bound co-factors α klotho and β klotho convert the HS FGFR1 signaling complex that normally responds to tissue FGFs to mediate cellular homeostasis in development and response to injury into an FGF21- and FGF23-controlled mediator of tissue-specific metabolic homeostasis.
The platelet calmodulin changes were attributed to paravertebral muscle activity, and a role for calmodulin in the etiopathogenesis of IS as a systemic mediator of tissues with contractile properties was suggested [ 60].
Key mediators of tissue remodelling following brain injury or disease-mediated insult include the MMPs (matrix metalloproteinases).
Background: Oxygen free radicals have been implicated as mediators of tissue damage in patients of rheumatoid arthritis (RA).
These deposits of foreign protein and complexes react with other protein components of blood (see the article complement) and attract to the site white blood cells and platelets, which also are circulating in the blood; these in turn release protease enzymes and other chemical mediators of tissue injury.
