Sentence examples for mediator of systemic from inspiring English sources

Results of recent studies indicate that a single intravenous dose of GLN supplementation ameliorated lung and kidney injury and increased survival in a cecal ligation and puncture (CLP -induced sepsis model by inhibition of the high-mobility group box protein-1 (HMGB-1)-mediated pathway, whiCLP -inducedht to be a late-sepsismodeltor of systemic damage [ 14, 15].

Stat1 is a key mediator of systemic IFN responses (Stark and Darnell, 2012).

These findings suggest that HMGB1 is an important mediator of systemic autophagic syndrome.

HMGB-1, recently known as the "late" proinflammatory mediator of systemic inflammation, has been shown to activate MAP kinase and NFκB signaling through RAGE (Sims et al. 2010).

HMGB1 is a non-histone nucleosomal protein which is expressed in all mammal cells, a critical mediator of systemic and local inflammation [ 7].

In animal models of infection or local tissue injury, HMGB1 functions as a critical mediator of systemic or local inflammatory injury [ 11].

TNF-α and IL-6 act through classical receptor-mediated processes, resulting in upregulation of potential mediators of systemic inflammation that can lead to insulin resistance.

In this complex scenario, our study was designed to verify the existence and strength of the association between selected mediators of systemic inflammation and classic risk factors of cardiovascular diseases (CVD).

With body mass index, adipokines, and mediators of systemic inflammation forced into a multivariable linear regression model with waist-to-hip ratio, we observed no significant attenuation of the effect of abdominal obesity on telomere shortening (Table 4).

For example, TNF-α is one of the key mediators of systemic endotoxemia.

In the cascade from invasion to inflammation, as one of the chemical mediators of systemic inflammation, the relationship of HMGB1 to the onset of AKI and ARDS has been pointed out.