Sentence examples for mediator of platelet from inspiring English sources
The platelet glycoprotein IIb/IIIa receptor is a key mediator of platelet aggregation and intracoronary thrombosis.
Aged mice displayed increased intraplatelet expression of p47 phox) and superoxide dismutase-1, suggesting a mechanistic pathway for increased hydrogen peroxide generation.Our findings demonstrate that hydrogen peroxide is a key mediator of platelet hyperactivity and enhanced thrombotic susceptibility in aged mice.
The clinical importance of the P2Y12 receptor as a mediator of platelet activation has become evident in several large-scale clinical studies and inhibition of the P2Y12 receptor with clopidogrel is one of the cornerstones in treatment and prevention of acute coronary syndromes [9].
Protein kinase C is an essential mediator of platelet activation.
ADP also promotes secretion of other materials from intracellular granules including P-selectin which is the prime mediator of platelet interactions with leucocytes [ 12].
Functioning both as a source of fibrin and as a mediator of platelet aggregation, it is the first coagulation factor to reach critically low levels during major blood loss and volume replacement.
Although our data indicate that EGFR-DNA-PK signalling is a major mediator of platelet-triggered cytoprotection, they do not exclude the contribution of other pro-survival signalling cascades.
Furthermore there were no significant differences regarding the other mediators of platelet aggregation such as TRAP or collagen.
We were able to demonstrate for the first time the role of MPO as mediator of human platelet activation.
Severe ADAMTS13 deficiency (activity generally < 10%) results in insufficient processing of von Willebrand factor (VWF) — a critical mediator of normal platelet tethering.
There is also evidence that soluble E-NPPases in plasma can degrade ADP directly to adenosine (Birk et al, 2002; Cauwenberghs et al, 2006), thus ectonucleotidases can convert prothrombotic mediators into inhibitors of platelet activation.
