Another mediator of OS-induced angiogenesis is ataxia-telangiectasia mutated (ATM) kinase, which was shown to promote only pathological neoangiogenesis [ 24].
Unlike phosphorylation, for which many kinases and phosphatases act either specifically or in large cascades through signal amplification, these two enzymes are currently the only identified mediators of the O-GlcNAc PTM.
O-GlcNAc-modified H2AX and MDC1 (mediator of DNA damage check point 1) are enriched at DNA damage foci, but suppress the expansion of DNA damage-produced phosphorylation at H2AX site39 site on the chromatin (Chen and Yu, 2016).
Wenext focused on transcriptional activation of forkhead box O following mTOR inhibition as a potential mediator of metabolic changes.
The mediator of the strong force was named the gluon.
Oxidative stress as a mediator of cardiovascular disease.
The emotional attachment is the important mediator of CSR success.
Axl as a mediator of cellular growth and survival.
Fig. 2: Working memory performance and mediator of depression recovery.
Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease.
Neuroplasticity accompanying learning is a key mediator of stroke rehabilitation.
