Sentence examples for mediator of multiple from inspiring English sources

In the liver, TGFβ is a critical mediator of multiple responses to injury [ 2].

TGFβ is another central mediator of multiple inflammatory and fibrotic cellular responses in cardiac remodeling [ 38].

In these pathways, the cell thiol redox state is a crucial mediator of multiple metabolic signaling and transcriptional processes.

Results: The glucocorticoid receptor pathway was computationally predicted to be a key mediator of multiple metal-induced birth defects.

By binding to several G-protein-coupled receptors it acts as pleiotropic mediator of multiple cellular effects [ 24].

The binding of neutrophil-derived myeloperoxidase to bovine aortic endothelial cells, a mediator of multiple oxidative and nitric oxide-consuming reactions, was also enhanced [ 20].

Tyrosine kinases are key mediators of multiple signaling pathways implicated in rheumatoid arthritis (RA).

Since all of the CCN family members are thought to be mediators of multiple signaling molecules, therapeutic utility of another member, such as CCN3/NOV is also expected and obviously, need to be explored.

The early asthmatic response (EAR) to inhaled allergen results from IgE-mediated release of multiple mast-cell mediators, including leukotrienes and histamine, both of which cause bronchoconstriction.

cPLA2 can perturb membrane phospholipids, and besides being a precursor for the synthesis of eicosanoids, AA is an important lipid mediator for regulation of multiple signalling pathways (Bazan, 2003).

The complexity of mediator interdependency may also require the targeting of multiple mediators simultaneously or combined targeting of pro- and anti-inflammatory mediators.