Sentence examples for mediator of hypoxic from inspiring English sources

Such effect could be greatly inhibited by siRNA-mediated knocking down of Nur77, demonstrating that endogenous Nur77 was a mediator of hypoxic activation of Akt.

DJ-1 has also been reported to act as a mediator of hypoxic preconditioning in H9c2 rat myoblasts.

A key mediator of hypoxic cell survival and adaptation is the hypoxia-inducible factor-1 (HIF-1) pathway (Semenza, 2000).

Our results show that the expression of hypoxia inducible factor 1alpha (HIF-1α), a key mediator of hypoxic responses, is elevated during the course of CIA in arthritic paws compared to healthy paws.

The transcriptional upregulation of noxa observed by conditions of OGD in vitro and focal ischemia in vivo is consistent with results reporting induction of noxa during hypoxia and after transient ischemia in vivo by Hif1 α as a mediator of hypoxic cell.

As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, which are involved in multiple aspects of tumorigenesis and cancer progression, including proliferation, metabolism, angiogenesis, invasion, metastasis and therapy resistance.

Given the essential roles of the actin cytoskeleton in aggressive hypoxic phenotypes, it is surprising that the actin cytoskeleton as a mediator of the hypoxic response has remained largely unexplored until recently [ 33].

The main mediator of the hypoxic regulation of genes is the transcription factor hypoxia-inducible factor (HIF).

In eukaryotic cells, hypoxia-inducible factor-1 (HIF-1) is a primary transcriptional mediator of the hypoxic response and master regulator of O2 homeostasis [ 26].

We identify miR-210-3p miR-210-3p miR-210-3pRNasthat acts as critical mediator of tHIFhypoxic regulatedand thus as an oncomiRNAn GBM.

As a key mediator of the hypoxic response in animal cells, HIF-1 plays an important role in controlling the glycolysis pathway when cells are exposed to low oxygen tension.